Alan V Boddy Selected Research

1- cyclopropyl- 3- (3- (5- morpholin- 4- ylmethyl- 1H- benzoimidazol- 2- yl)- 1H- pyrazol- 4- yl)urea

1/2017	A population pharmacokinetic model of AT9283 in adults and children to predict the maximum tolerated dose in children with leukaemia.
1/2015	A phase I trial of AT9283 (a selective inhibitor of aurora kinases) in children and adolescents with solid tumors: a Cancer Research UK study.

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Alan V Boddy Research Topics

Disease

27	Neoplasms (Cancer) 10/2022 - 05/2003
7	Breast Neoplasms (Breast Cancer) 01/2017 - 06/2009
5	Neuroblastoma 01/2013 - 01/2002
4	Melanoma (Melanoma, Malignant) 01/2019 - 05/2005
4	Body Weight (Weight, Body) 01/2017 - 10/2004
3	Neutropenia 01/2015 - 11/2005
3	Ovarian Neoplasms (Ovarian Cancer) 01/2012 - 03/2007
2	Cardiotoxicity 01/2021 - 12/2016
2	Non-Hodgkin Lymphoma (Lymphosarcoma) 03/2016 - 01/2004
2	Thrombocytopenia (Thrombopenia) 01/2015 - 11/2007
2	Rhabdomyosarcoma 01/2008 - 10/2003
1	COVID-19 10/2022
1	Obesity 01/2021
1	Lymphoma (Lymphomas) 01/2021
1	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 01/2020
1	Fever (Fevers) 01/2019
1	Colorectal Neoplasms (Colorectal Cancer) 09/2017
1	Infections 01/2017
1	Hepatocellular Carcinoma (Hepatoma) 01/2016
1	Brain Neoplasms (Brain Tumor) 12/2015
1	Glioblastoma (Glioblastoma Multiforme) 12/2015
1	Lung Neoplasms (Lung Cancer) 08/2015
1	Anemia 01/2015
1	Flushing 06/2014
1	Retinoblastoma (Glioblastoma, Retinal) 09/2012
1	Leukemia 10/2011
1	Wilms Tumor (Wilm's Tumor) 01/2008
1	Disease Progression 11/2007
1	BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia) 07/2007
1	Urinary Bladder Neoplasms (Bladder Cancer) 03/2007
1	Neoplasm Metastasis (Metastasis) 03/2007

Drug/Important Bio-Agent (IBA)

13	Pharmaceutical PreparationsIBA 10/2022 - 10/2003
7	Doxorubicin (Adriamycin)FDA LinkGeneric 01/2021 - 10/2011
6	Dactinomycin (Actinomycin)FDA LinkGeneric 12/2018 - 10/2003
6	Carboplatin (JM8)FDA LinkGeneric 09/2012 - 08/2002
5	Cyclophosphamide (Cytoxan)FDA LinkGeneric 01/2017 - 01/2004
4	DNA (Deoxyribonucleic Acid)IBA 03/2016 - 02/2009
3	AnthracyclinesIBA 01/2021 - 12/2011
3	Temozolomide (Temodar)FDA LinkGeneric 12/2015 - 05/2005
2	Imatinib Mesylate (Gleevec)FDA Link 10/2022 - 07/2007
2	Interleukin-6 (Interleukin 6)IBA 10/2022 - 01/2019
2	Biomarkers (Surrogate Marker)IBA 01/2021 - 01/2016
2	Drug CombinationsIBA 01/2020 - 08/2002
2	Monoclonal AntibodiesIBA 01/2019 - 06/2009
2	dabrafenibIBA 01/2019 - 01/2017
2	trametinibIBA 01/2019 - 01/2017
2	1- cyclopropyl- 3- (3- (5- morpholin- 4- ylmethyl- 1H- benzoimidazol- 2- yl)- 1H- pyrazol- 4- yl)ureaIBA 01/2017 - 01/2015
2	Aromatase InhibitorsIBA 11/2016 - 08/2016
2	rucaparibIBA 12/2015 - 02/2009
2	Poly(ADP-ribose) Polymerase InhibitorsIBA 12/2015 - 02/2009
2	Isotretinoin (Accutane)FDA LinkGeneric 01/2013 - 07/2010
2	NRH - quinone oxidoreductase2IBA 12/2011 - 03/2007
2	Tretinoin (Retinoic Acid)FDA LinkGeneric 07/2010 - 01/2002
2	Etoposide (VP 16)FDA LinkGeneric 05/2010 - 09/2006
2	Poly (ADP-Ribose) Polymerase-1IBA 02/2009 - 05/2005
2	Paclitaxel (Taxol)FDA LinkGeneric 11/2007 - 11/2005
1	Dexamethasone (Maxidex)FDA LinkGeneric 10/2022
1	Glycoproteins (Glycoprotein)IBA 10/2022
1	AcidsIBA 10/2022
1	Clofarabine (Clolar)FDA Link 01/2020
1	CytokinesIBA 01/2019
1	Mitogen-Activated Protein Kinase Kinases (MEKs)IBA 01/2019
1	CurcuminIBA 09/2017
1	TroponinIBA 12/2016
1	Natriuretic PeptidesIBA 12/2016
1	Carotenoids (Carotene)IBA 10/2016
1	retinol acetateIBA 10/2016
1	Vitamin A (Retinol)FDA LinkGeneric 10/2016
1	Estrogen ReceptorsIBA 08/2016
1	human ERBB2 proteinIBA 03/2016
1	Indicators and Reagents (Reagents)IBA 03/2016
1	ErbB Receptors (EGF Receptor)IBA 03/2016
1	Silk FDA Link 08/2015
1	Drug CarriersIBA 08/2015
1	Aurora KinasesIBA 01/2015
1	Aurora Kinase AIBA 01/2015
1	Alkylating AgentsIBA 10/2014
1	Fluorouracil (Carac)FDA LinkGeneric 10/2014
1	Epirubicin (Ellence)FDA LinkGeneric 10/2014
1	carboplatin-DNA adductIBA 01/2012
1	Tamoxifen FDA LinkGeneric 12/2011
1	Trastuzumab (Herceptin)FDA Link 06/2009
1	Oncogene Proteins (Oncogene Protein)IBA 06/2009
1	Antisense OligonucleotidesIBA 05/2009
1	MethyltransferasesIBA 05/2009
1	Topotecan (Hycamtin)FDA LinkGeneric 02/2009
1	ixabepilone (BMS 247550)FDA Link 12/2008
1	quinone (benzoquinone)IBA 03/2007
1	Messenger RNA (mRNA)IBA 03/2007
1	Oxidoreductases (Dehydrogenase)IBA 03/2007
1	tretazicarIBA 03/2007
1	NAD (NADH)IBA 03/2007

Therapy/Procedure

10	Therapeutics 01/2021 - 03/2007
4	Drug Therapy (Chemotherapy) 01/2021 - 01/2004
3	Oral Administration 10/2016 - 05/2003
1	Duration of Therapy 01/2021
1	Immunotherapy 01/2019
1	Precision Medicine 11/2016
1	Lasers (Laser) 12/2015
1	Cytoreduction Surgical Procedures 11/2007